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PT-141

Boost intimacy and enhance desire!
PT-141 stimulates the brain’s arousal centers through the melanocortin system

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Bremelanotide Injection
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PT-141

PT-141 (Bremelanotide) is a centrally acting melanocortin receptor agonist used to enhance sexual desire and arousal in both men and women. Originally developed to treat sexual dysfunction, it is FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women and is also commonly used off-label in men with low libido or erectile dysfunction—especially when psychological or central causes are suspected. Unlike traditional ED medications, PT-141 works through the brain rather than blood flow.

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How does it work?

CNS-Based Arousal Enhancement

PT-141 activates melanocortin receptors (MC3R and MC4R) in the hypothalamus, increasing sexual desire and drive by acting on the central nervous system.

Independent of Blood Flow

Unlike PDE5 inhibitors (like sildenafil or tadalafil), PT-141 does not depend on nitric oxide pathways or vascular mechanisms—making it effective for both genders and for arousal-related dysfunction.

Rapid, On-Demand Effect

Administered via subcutaneous injection 45–60 minutes before sexual activity, PT-141 enhances arousal, responsiveness, and sensitivity for several hours.

Benefits

Increases sexual desire in men and women
Effective for psychological and neurological libido issues
Can help men with ED unresponsive to PDE5 inhibitors
Enhances physical arousal, sensation, and orgasmic response
FDA-approved for HSDD in women
Non-hormonal and well tolerated
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Frequently Asked Questions

PT-141 (Bremelanotide) is a centrally acting melanocortin receptor agonist used to enhance sexual desire and arousal in both men and women. Originally developed to treat sexual dysfunction, it is FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women and is also commonly used off-label in men with low libido or erectile dysfunction—especially when psychological or central causes are suspected. Unlike traditional ED medications, PT-141 works through the brain rather than blood flow.

  • Inject 1 hour before sexual activity (typically 1.75mg dose)
  • Onset: 45–60 minutes, duration: 6–12 hours
  • Do not exceed 1 dose in 24 hours or 8 doses per month (per FDA guidelines for women)
  • Results improve with repeated, consistent use over time
  • Safe to combine with TRT, HRT, or PDE5s (under supervision)
  • Missed dose? PT-141 is on-demand—only use when needed

Common Side Effects:

  • Nausea (transient)
  • Flushing or warmth
  • Headache
  • Injection site reactions

Less Common / Monitor If Present:

  • Elevated blood pressure (temporary)
  • Fatigue or yawning
  • Dizziness
  • Darkening of gums or skin (rare with prolonged use)
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